Lets Talk Botox Resistance

Botox Resistance: Why Sometimes Your Body Says “No”

Botox is amazing for smoothing wrinkles and treating certain conditions but sometimes, after a few treatments, it might stop working as well as it use-to. This is called Botox resistance, and it usually comes down to your immune system.

How Botox Works

Botox is a purified protein called botulinum toxin. It works by relaxing the muscles that cause wrinkles. But here’s the thing, your body can see Botox as a foreign protein, and sometimes it decides to fight back. ( often for those that have been having regular Tox for years however your body can react after even one treatment)

Meet the Gatekeeper: Your Dendritic Cells

Your immune system has a “gatekeeper” called a dendritic cell. Think of it like a bouncer at a nightclub, they check anything that enters your body. If they think Botox is a threat, they alert your immune system (T-cells) to create antibodies that block it. This is what leads to resistance. the key is not to activate the alarm!!!

Why Top-Ups Aren’t Always a Good Idea

This is why a top-up isn’t always the best although we all love what seems like a sneaky little free top up!!. some cases of course we do need to so if you do need one, it should be very minimal just 1–4 units. Overdoing it can actually increase the chance of your body building resistance by re-triggering the antibody response such a short period after.

What You Can Do

Botox resistance is rare about, 1% of patients, but if you happen to be that 1%, it can be frustrating. In my clinic, Kylie Jane Cosmetics we have products and strategies to help prevent resistance.

If you think you might be resistant, we offer a Resistance Consultation to assess your situation and plan the best approach.

Bottom Line

Botox works beautifully for most people, but your immune system and those ever-vigilant dendritic “gatekeeper” cells can sometimes fight back. By being careful with top-ups and following our guidance, you can keep your treatments working well for years.

Prevent the inevitable

*Don't Cosmetic treatment shop, we know if you have had a treatment elsewhere and our team will not treat you, and i would hope that other Clinics will follow suit.

*Try to stretch out your treatments, if slight movement returns you still have tox in your body and dont need an immediate treatment.

*If you start Tox in your 20s, as i did, thats ok however think of the future you, who wont like you very much if she becomes resistant at 40-50 when she may need it most!

* Think about if you acquire a medical condition requiring treatment with tox and your body has gained a resistant through to many antibodies reacting and you can not be helped by the one treatment you may need!

Just a little food for thought................

A little analogy that may help. Think of it like, every time you have a tox treatment you are vaccinating yourself.

We get the Flu vaccine annually as once injected the dendrite cell activates antibodies to fight the forgen object, so lots of antibodies are active so that when you get the flu your body recognises it as an invader and fights immediately.

Same thing when getting Toxin, except we are getting toxin much more frequently than annually!!